Silent mutations at codons 65 and 66 in reverse transcriptase alleviate indel formation and restore fitness in subtype B HIV-1 containing D67N and K70R drug resistance mutations

Resistance to combined antiretroviral therapy (cART) in HIV-1-infected individuals is typically due to nonsynonymous mutations that change the protein sequence; however, the selection of synonymous or ‘silent’ mutations in the HIV-1 genome with cART has been reported. These silent K65K and K66K muta...

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Detalles Bibliográficos
Autores principales: Telwatte, Sushama, Hearps, Anna C., Johnson, Adam, Latham, Catherine F., Moore, Katie, Agius, Paul, Tachedjian, Mary, Sonza, Secondo, Sluis-Cremer, Nicolas, Harrigan, P. Richard, Tachedjian, Gilda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381058/
https://www.ncbi.nlm.nih.gov/pubmed/25765644
http://dx.doi.org/10.1093/nar/gkv128

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381058/
https://www.ncbi.nlm.nih.gov/pubmed/25765644
http://dx.doi.org/10.1093/nar/gkv128

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