A genome-wide analysis of Cas9 binding specificity using ChIP-seq and targeted sequence capture

Clustered regularly interspaced short palindromic repeat (CRISPR) RNA-guided nucleases have gathered considerable excitement as a tool for genome engineering. However, questions remain about the specificity of target site recognition. Cleavage specificity is typically evaluated by low throughput ass...

Descripción completa

Detalles Bibliográficos
Autores principales: O'Geen, Henriette, Henry, Isabelle M., Bhakta, Mital S., Meckler, Joshua F., Segal, David J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Synthetic Biology and Bioengineering
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381059/
https://www.ncbi.nlm.nih.gov/pubmed/25712100
http://dx.doi.org/10.1093/nar/gkv137

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381059/
https://www.ncbi.nlm.nih.gov/pubmed/25712100
http://dx.doi.org/10.1093/nar/gkv137

Ejemplares similares