U1 snRNP is mislocalized in ALS patient fibroblasts bearing NLS mutations in FUS and is required for motor neuron outgrowth in zebrafish

Mutations in FUS cause amyotrophic lateral sclerosis (ALS), but the molecular pathways leading to neurodegeneration remain obscure. We previously found that U1 snRNP is the most abundant FUS interactor. Here, we report that components of the U1 snRNP core particle (Sm proteins and U1 snRNA), but not...

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Detalles Bibliográficos
Autores principales: Yu, Yong, Chi, Binkai, Xia, Wei, Gangopadhyay, Jaya, Yamazaki, Tomohiro, Winkelbauer-Hurt, Marlene E., Yin, Shanye, Eliasse, Yoan, Adams, Edward, Shaw, Christopher E., Reed, Robin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Molecular Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381066/
https://www.ncbi.nlm.nih.gov/pubmed/25735748
http://dx.doi.org/10.1093/nar/gkv157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381066/
https://www.ncbi.nlm.nih.gov/pubmed/25735748
http://dx.doi.org/10.1093/nar/gkv157

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