Cwc21p promotes the second step conformation of the spliceosome and modulates 3′ splice site selection

Pre-mRNA splicing involves two transesterification steps catalyzed by the spliceosome. How RNA substrates are positioned in each step and the molecular rearrangements involved, remain obscure. Here, we show that mutations in PRP16, PRP8, SNU114 and the U5 snRNA that affect this process interact gene...

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Detalles Bibliográficos
Autores principales: Gautam, Amit, Grainger, Richard J., Vilardell, J., Barrass, J. David, Beggs, Jean D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381068/
https://www.ncbi.nlm.nih.gov/pubmed/25740649
http://dx.doi.org/10.1093/nar/gkv159

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381068/
https://www.ncbi.nlm.nih.gov/pubmed/25740649
http://dx.doi.org/10.1093/nar/gkv159

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