Cargando…

An intrinsically disordered region of methyl-CpG binding domain protein 2 (MBD2) recruits the histone deacetylase core of the NuRD complex

The MBD2-NuRD (Nucleosome Remodeling and Deacetylase) complex is an epigenetic reader of DNA methylation that regulates genes involved in normal development and neoplastic diseases. To delineate the architecture and functional interactions of the MBD2-NuRD complex, we previously solved the structure...

Descripción completa

Detalles Bibliográficos
Autores principales:	Desai, Megha A., Webb, Heather D., Sinanan, Leander M., Scarsdale, J. Neel, Walavalkar, Ninad M., Ginder, Gordon D., Williams, David C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2015
Materias:	Gene regulation, Chromatin and Epigenetics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381075/ https://www.ncbi.nlm.nih.gov/pubmed/25753662 http://dx.doi.org/10.1093/nar/gkv168

Ejemplares similares

Localization of Drosophila CENP-A to non-centromeric sites depends on the NuRD complex
por: Demirdizen, Engin, et al.
Publicado: (2019)

The proto-oncoprotein FBI-1 interacts with MBD3 to recruit the Mi-2/NuRD-HDAC complex and BCoR and to silence p21WAF/CDKN1A by DNA methylation
por: Choi, Won-Il, et al.
Publicado: (2013)

CHD3 and CHD4 form distinct NuRD complexes with different yet overlapping functionality
por: Hoffmeister, Helen, et al.
Publicado: (2017)

Direct interaction between the PRDM3 and PRDM16 tumor suppressors and the NuRD chromatin remodeling complex
por: Ivanochko, Danton, et al.
Publicado: (2019)

Differential roles for MBD2 and MBD3 at methylated CpG islands, active promoters and binding to exon sequences
por: Günther, Katharina, et al.
Publicado: (2013)

Disruption of the MBD2-NuRD complex but not MBD3-NuRD induces high level HbF expression in human adult erythroid cells
por: Yu, Xiaofei, et al.
Publicado: (2019)

Insight into the Architecture of the NuRD Complex: STRUCTURE OF THE RbAp48-MTA1 SUBCOMPLEX
por: Alqarni, Saad S. M., et al.
Publicado: (2014)

Recruitment of MBD1 to target genes requires sequence-specific interaction of the MBD domain with methylated DNA
por: Clouaire, Thomas, et al.
Publicado: (2010)

Characterization of Two Distinct Nucleosome Remodeling and Deacetylase (NuRD) Complex Assemblies in Embryonic Stem Cells
por: Bode, Daniel, et al.
Publicado: (2016)

Mbd2-CP2c loop drives adult-type globin gene expression and definitive erythropoiesis
por: Kim, Min Young, et al.
Publicado: (2018)

Insights into Association of the NuRD Complex with FOG-1 from the Crystal Structure of an RbAp48·FOG-1 Complex
por: Lejon, Sara, et al.
Publicado: (2011)

The impact of intragenic CpG content on gene expression
por: Bauer, Asli Petra, et al.
Publicado: (2010)

No evidence of extensive non-CpG methylation in mtDNA
por: Guitton, Romain, et al.
Publicado: (2022)

Cytosine methylation at CpCpG sites triggers accumulation of non-CpG methylation in gene bodies
por: Zabet, Nicolae Radu, et al.
Publicado: (2017)

CpG domains downstream of TSSs promote high levels of gene expression
por: Krinner, Simone, et al.
Publicado: (2014)

Implications of CpG islands on chromosomal architectures and modes of global gene regulation
por: Beck, Samuel, et al.
Publicado: (2018)

DNA methylation in human epigenomes depends on local topology of CpG sites
por: Lövkvist, Cecilia, et al.
Publicado: (2016)

Human mitochondrial DNA is extensively methylated in a non-CpG context
por: Patil, Vibha, et al.
Publicado: (2019)

The homeodomain of Oct4 is a dimeric binder of methylated CpG elements
por: Tan, Daisylyn Senna, et al.
Publicado: (2023)

Dissecting the behavior and function of MBD3 in DNA methylation homeostasis by single-molecule spectroscopy and microscopy
por: Cui, Yi, et al.
Publicado: (2015)

Binding of MBD proteins to DNA blocks Tet1 function thereby modulating transcriptional noise
por: Ludwig, Anne K., et al.
Publicado: (2017)

Protection of CpG islands from DNA methylation is DNA-encoded and evolutionarily conserved
por: Long, Hannah K., et al.
Publicado: (2016)

Accumulation and loss of asymmetric non-CpG methylation during male germ-cell development
por: Ichiyanagi, Tomoko, et al.
Publicado: (2013)

MLL fusion proteins link transcriptional coactivators to previously active CpG-rich promoters
por: Okuda, Hiroshi, et al.
Publicado: (2014)

Collaboration between CpG sites is needed for stable somatic inheritance of DNA methylation states
por: Haerter, Jan O., et al.
Publicado: (2014)

Effects of non-CpG site methylation on DNA thermal stability: a fluorescence study
por: Nardo, Luca, et al.
Publicado: (2015)

GC skew is a conserved property of unmethylated CpG island promoters across vertebrates
por: Hartono, Stella R., et al.
Publicado: (2015)

Strand-specific CpG hemimethylation, a novel epigenetic modification functional for genomic imprinting
por: Patiño-Parrado, Iris, et al.
Publicado: (2017)

DNA strand asymmetry generated by CpG hemimethylation has opposing effects on CTCF binding
por: Thomas, Stacey L, et al.
Publicado: (2023)

MBD-isolated Genome Sequencing provides a high-throughput and comprehensive survey of DNA methylation in the human genome
por: Serre, David, et al.
Publicado: (2010)

CpG methylation potentiates pixantrone and doxorubicin-induced DNA damage and is a marker of drug sensitivity
por: Evison, Benny J., et al.
Publicado: (2009)

A primary role of TET proteins in establishment and maintenance of De Novo bivalency at CpG islands
por: Kong, Lingchun, et al.
Publicado: (2016)

Characterization of the ZFX family of transcription factors that bind downstream of the start site of CpG island promoters
por: Ni, Weiya, et al.
Publicado: (2020)

Transcription of intragenic CpG islands influences spatiotemporal host gene pre-mRNA processing
por: Amante, Samuele M, et al.
Publicado: (2020)

Single-molecule mitochondrial DNA sequencing shows no evidence of CpG methylation in human cells and tissues
por: Bicci, Iacopo, et al.
Publicado: (2021)

Excision of thymine and 5-hydroxymethyluracil by the MBD4 DNA glycosylase domain: structural basis and implications for active DNA demethylation
por: Hashimoto, Hideharu, et al.
Publicado: (2012)

Dynamics of MBD2 deposition across methylated DNA regions during malignant transformation of human mammary epithelial cells
por: Devailly, Guillaume, et al.
Publicado: (2015)

Differences in DNA methylation between human neuronal and glial cells are concentrated in enhancers and non-CpG sites
por: Kozlenkov, Alexey, et al.
Publicado: (2014)

Genome-wide CpG island methylation and intergenic demethylation propensities vary among different tumor sites
por: Lee, Seung-Tae, et al.
Publicado: (2016)

Solution structure and intramolecular exchange of methyl-cytosine binding domain protein 4 (MBD4) on DNA suggests a mechanism to scan for (m)CpG/TpG mismatches
por: Walavalkar, Ninad M., et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_h0ia2lg6j1f895cfn1me9uvtek