Effects of DNA(3′)pp(5′)G capping on 3′ end repair reactions and of an embedded pyrophosphate-linked guanylate on ribonucleotide surveillance

When DNA breakage results in a 3′-PO(4) terminus, the end is considered ‘dirty’ because it cannot prime repair synthesis by DNA polymerases or sealing by classic DNA ligases. The noncanonical ligase RtcB can guanylylate the DNA 3′-PO(4) to form a DNA(3′)pp(5′)G(OH) cap. Here we show that DNA capping...

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Detalles Bibliográficos
Autores principales: Chauleau, Mathieu, Das, Ushati, Shuman, Stewart
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2015
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381079/
https://www.ncbi.nlm.nih.gov/pubmed/25753667
http://dx.doi.org/10.1093/nar/gkv179

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381079/
https://www.ncbi.nlm.nih.gov/pubmed/25753667
http://dx.doi.org/10.1093/nar/gkv179

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