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Effects of DNA(3′)pp(5′)G capping on 3′ end repair reactions and of an embedded pyrophosphate-linked guanylate on ribonucleotide surveillance
When DNA breakage results in a 3′-PO(4) terminus, the end is considered ‘dirty’ because it cannot prime repair synthesis by DNA polymerases or sealing by classic DNA ligases. The noncanonical ligase RtcB can guanylylate the DNA 3′-PO(4) to form a DNA(3′)pp(5′)G(OH) cap. Here we show that DNA capping...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Oxford University Press
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381079/ https://www.ncbi.nlm.nih.gov/pubmed/25753667 http://dx.doi.org/10.1093/nar/gkv179 |