Cargando…

Treatment of cardiac arrhythmias in a mouse model of Rett syndrome with Na(+)-channel-blocking antiepileptic drugs

One quarter of deaths associated with Rett syndrome (RTT), an X-linked neurodevelopmental disorder, are sudden and unexpected. RTT is associated with prolonged QTc interval (LQT), and LQT-associated cardiac arrhythmias are a potential cause of unexpected death. The standard of care for LQT in RTT is...

Descripción completa

Detalles Bibliográficos
Autores principales:	Herrera, José A., Ward, Christopher S., Pitcher, Meagan R., Percy, Alan K., Skinner, Steven, Kaufmann, Walter E., Glaze, Daniel G., Wehrens, Xander H. T., Neul, Jeffrey L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Company of Biologists Limited 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381335/ https://www.ncbi.nlm.nih.gov/pubmed/25713300 http://dx.doi.org/10.1242/dmm.020131

Ejemplares similares

Loss of MeCP2 Causes Urological Dysfunction and Contributes to Death by Kidney Failure in Mouse Models of Rett Syndrome
por: Ward, Christopher S., et al.
Publicado: (2016)

Metabolic Signatures Differentiate Rett Syndrome From Unaffected Siblings
por: Neul, Jeffrey L., et al.
Publicado: (2020)

A review of the Rett Syndrome Behaviour Questionnaire and its utilization in the assessment of symptoms associated with Rett syndrome
por: Percy, Alan K., et al.
Publicado: (2023)

Developmental delay in Rett syndrome: data from the natural history study
por: Neul, Jeffrey L, et al.
Publicado: (2014)

Double-blind, randomized, placebo-controlled study of trofinetide in pediatric Rett syndrome
por: Glaze, Daniel G., et al.
Publicado: (2019)

Enrichment of mutations in chromatin regulators in people with Rett Syndrome lacking mutations in MECP2
por: Sajan, Samin A., et al.
Publicado: (2016)

When Rett syndrome is due to genes other than MECP2
por: Percy, Alan K., et al.
Publicado: (2018)

Trofinetide for the treatment of Rett syndrome: a randomized phase 3 study
por: Neul, Jeffrey L., et al.
Publicado: (2023)

Multisystem comorbidities in classic Rett syndrome: a scoping review
por: Fu, Cary, et al.
Publicado: (2020)

Consensus guidelines on managing Rett syndrome across the lifespan
por: Fu, Cary, et al.
Publicado: (2020)

Anxiety-like behavior and anxiolytic treatment in the Rett syndrome natural history study
por: Buchanan, Caroline B., et al.
Publicado: (2022)

Treatments for cardiac arrhythmias in Rett syndrome
Publicado: (2015)

Genome Editing and Cardiac Arrhythmias
por: Moore, Oliver M., et al.
Publicado: (2023)

Neurobiologically-based treatments in Rett syndrome: opportunities and challenges
por: Kaufmann, Walter E., et al.
Publicado: (2016)

The relationship of Rett syndrome and MECP2 disorders to autism
por: Neul, Jeffrey Lorenz
Publicado: (2012)

Progress in Rett Syndrome: from discovery to clinical trials
por: Percy, Alan K.
Publicado: (2016)

Top Caregiver Concerns in Rett syndrome and related disorders: data from the US Natural History Study
por: Neul, Jeffrey Lorenz, et al.
Publicado: (2023)

Top caregiver concerns in Rett syndrome and related disorders: data from the US natural history study
por: Neul, Jeffrey L., et al.
Publicado: (2023)

Loss of MeCP2 in the rat models regression, impaired sociability and transcriptional deficits of Rett syndrome
por: Veeraragavan, Surabi, et al.
Publicado: (2016)

Analysis of X‐inactivation status in a Rett syndrome natural history study cohort
por: Fang, Xiaolan, et al.
Publicado: (2022)

The sodium channel-blocking antiepileptic drug phenytoin inhibits breast tumour growth and metastasis
por: Nelson, Michaela, et al.
Publicado: (2015)

Rett Syndrome and MECP2 Duplication Syndrome: Disorders of MeCP2 Dosage
por: Collins, Bridget E, et al.
Publicado: (2022)

Lacosamide and sodium channel‐blocking antiepileptic drug cross‐titration against levetiracetam background therapy
por: Baulac, M., et al.
Publicado: (2016)

Curcumin, a Multi-Ion Channel Blocker That Preferentially Blocks Late Na(+) Current and Prevents I/R-Induced Arrhythmias
por: Song, Lv, et al.
Publicado: (2020)

CRISPR‐Mediated Expression of the Fetal Scn5a Isoform in Adult Mice Causes Conduction Defects and Arrhythmias
por: Pang, Paul D., et al.
Publicado: (2018)

Editorial: Inherited Arrhythmias of the Cardiac Sodium Channel Na(v)1.5
por: Amarouch, Mohamed-Yassine, et al.
Publicado: (2021)

Molecular Signatures of Response to Mecasermin in Children With Rett Syndrome
por: Shovlin, Stephen, et al.
Publicado: (2022)

MeCP2 in the regulation of neural activity: Rett syndrome pathophysiological perspectives
por: Cuddapah, Vishnu Anand, et al.
Publicado: (2015)

Assessment of the gut bacterial microbiome and metabolome of girls and women with Rett Syndrome
por: Thapa, Santosh, et al.
Publicado: (2021)

Changing the perspective on early development of Rett syndrome
por: Marschik, Peter B., et al.
Publicado: (2013)

A privileged role for neuronal Na(+) channels in regulating ventricular [Ca(2+)] and arrhythmias
por: Jones, DeAnalisa C., et al.
Publicado: (2018)

Unraveling the Mechanisms by Which Calpain Inhibition Prevents Heart Failure Development
por: Wehrens, Xander H.T.
Publicado: (2018)

Levetiracetam Liver Injury: A Benign Antiepileptic Agent?
por: Hegazy, Yassmin, et al.
Publicado: (2023)

Effect of Na(+) Flow on Cd(2+) Block of Tetrodotoxin-resistant Na(+) Channels
por: Kuo, Chung-Chin, et al.
Publicado: (2002)

Peculiarities in the gestural repertoire: An early marker for Rett syndrome?
por: Marschik, Peter B., et al.
Publicado: (2012)

Na(+) Permeation and Block of hERG Potassium Channels
por: Gang, Hongying, et al.
Publicado: (2006)

Kinetics of 9-aminoacridine block of single Na channels
Publicado: (1984)

Safety and efficacy of genetic MECP2 supplementation in the R294X mouse model of Rett syndrome
por: Collins, Bridget E., et al.
Publicado: (2021)

Enhanced impact of SCN5A mutation associated with long QT syndrome in fetal splice isoform
por: Wang, Tiannan, et al.
Publicado: (2011)

Batrachotoxin-activated Na+ channels in planar lipid bilayers. Competition of tetrodotoxin block by Na+
Publicado: (1984)

Cannot write session to /tmp/vufind_sessions/sess_kqr31vn5kp951ff1a3ul0vjngc