Systematic identification of cancer driving signaling pathways based on mutual exclusivity of genomic alterations

We present a novel method for the identification of sets of mutually exclusive gene alterations in a given set of genomic profiles. We scan the groups of genes with a common downstream effect on the signaling network, using a mutual exclusivity criterion that ensures that each gene in the group sign...

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Detalles Bibliográficos
Autores principales: Babur, Özgün, Gönen, Mithat, Aksoy, Bülent Arman, Schultz, Nikolaus, Ciriello, Giovanni, Sander, Chris, Demir, Emek
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2015
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381444/
https://www.ncbi.nlm.nih.gov/pubmed/25887147
http://dx.doi.org/10.1186/s13059-015-0612-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381444/
https://www.ncbi.nlm.nih.gov/pubmed/25887147
http://dx.doi.org/10.1186/s13059-015-0612-6

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