Cargando…
Systematic identification of cancer driving signaling pathways based on mutual exclusivity of genomic alterations
We present a novel method for the identification of sets of mutually exclusive gene alterations in a given set of genomic profiles. We scan the groups of genes with a common downstream effect on the signaling network, using a mutual exclusivity criterion that ensures that each gene in the group sign...
| Autores principales: | , , , , , , |
|---|---|
| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
BioMed Central
2015
|
| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381444/ https://www.ncbi.nlm.nih.gov/pubmed/25887147 http://dx.doi.org/10.1186/s13059-015-0612-6 |