Whole-epigenome analysis in multiple myeloma reveals DNA hypermethylation of B cell-specific enhancers

While analyzing the DNA methylome of multiple myeloma (MM), a plasma cell neoplasm, by whole-genome bisulfite sequencing and high-density arrays, we observed a highly heterogeneous pattern globally characterized by regional DNA hypermethylation embedded in extensive hypomethylation. In contrast to t...

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Detalles Bibliográficos
Autores principales: Agirre, Xabier, Castellano, Giancarlo, Pascual, Marien, Heath, Simon, Kulis, Marta, Segura, Victor, Bergmann, Anke, Esteve, Anna, Merkel, Angelika, Raineri, Emanuele, Agueda, Lidia, Blanc, Julie, Richardson, David, Clarke, Laura, Datta, Avik, Russiñol, Nuria, Queirós, Ana C., Beekman, Renée, Rodríguez-Madoz, Juan R., José-Enériz, Edurne San, Fang, Fang, Gutiérrez, Norma C., García-Verdugo, José M., Robson, Michael I., Schirmer, Eric C., Guruceaga, Elisabeth, Martens, Joost H.A., Gut, Marta, Calasanz, Maria J., Flicek, Paul, Siebert, Reiner, Campo, Elías, Miguel, Jesús F. San, Melnick, Ari, Stunnenberg, Hendrik G., Gut, Ivo G., Prosper, Felipe, Martín-Subero, José I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381520/
https://www.ncbi.nlm.nih.gov/pubmed/25644835
http://dx.doi.org/10.1101/gr.180240.114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381520/
https://www.ncbi.nlm.nih.gov/pubmed/25644835
http://dx.doi.org/10.1101/gr.180240.114

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