Effect of minichromosome maintenance protein 2 deficiency on the locations of DNA replication origins

Minichromosome maintenance (MCM) proteins are loaded onto chromatin during G1-phase and define potential locations of DNA replication initiation. MCM protein deficiency results in genome instability and high rates of cancer in mouse models. Here we develop a method of nascent strand capture and rele...

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Detalles Bibliográficos
Autores principales: Kunnev, Dimiter, Freeland, Amy, Qin, Maochun, Leach, Robert W., Wang, Jianmin, Shenoy, Rajani M., Pruitt, Steven C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2015
Materias:
Method
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381527/
https://www.ncbi.nlm.nih.gov/pubmed/25762552
http://dx.doi.org/10.1101/gr.176099.114

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381527/
https://www.ncbi.nlm.nih.gov/pubmed/25762552
http://dx.doi.org/10.1101/gr.176099.114

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