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Effect of minichromosome maintenance protein 2 deficiency on the locations of DNA replication origins

Minichromosome maintenance (MCM) proteins are loaded onto chromatin during G1-phase and define potential locations of DNA replication initiation. MCM protein deficiency results in genome instability and high rates of cancer in mouse models. Here we develop a method of nascent strand capture and rele...

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Detalles Bibliográficos
Autores principales:	Kunnev, Dimiter, Freeland, Amy, Qin, Maochun, Leach, Robert W., Wang, Jianmin, Shenoy, Rajani M., Pruitt, Steven C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2015
Materias:	Method
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381527/ https://www.ncbi.nlm.nih.gov/pubmed/25762552 http://dx.doi.org/10.1101/gr.176099.114

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