Binding-Pocket and Lid-Region Substitutions Render Human STING Sensitive to the Species-Specific Drug DMXAA

The drug DMXAA (5,6-dimethylxanthenone-4-acetic acid) showed therapeutic promise against solid tumors in mouse models but subsequently failed in human clinical trials. DMXAA was later discovered to activate mouse, but not human, STING, an adaptor protein in the cyclic dinucleotide cGAMP-mediated sig...

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Detalles Bibliográficos
Autores principales: Gao, Pu, Zillinger, Thomas, Wang, Weiyi, Ascano, Manuel, Dai, Peihong, Hartmann, Gunther, Tuschl, Thomas, Deng, Liang, Barchet, Winfried, Patel, Dinshaw J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381552/
https://www.ncbi.nlm.nih.gov/pubmed/25199835
http://dx.doi.org/10.1016/j.celrep.2014.08.010

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381552/
https://www.ncbi.nlm.nih.gov/pubmed/25199835
http://dx.doi.org/10.1016/j.celrep.2014.08.010

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