DNA damage-induced S and G2/M cell cycle arrest requires mTORC2-dependent regulation of Chk1

mTOR signalling is commonly dysregulated in cancer. Concordantly, mTOR inhibitors have demonstrated efficacy in a subset of tumors and are in clinical trials as combination therapies. Although mTOR is associated with promoting cell survival after DNA damage, the exact mechanisms are not well underst...

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Detalles Bibliográficos
Autores principales: Selvarajah, Jogitha, Elia, Androulla, Carroll, Veronica A., Moumen, Abdeladim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381605/
https://www.ncbi.nlm.nih.gov/pubmed/25460505

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381605/
https://www.ncbi.nlm.nih.gov/pubmed/25460505

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