DNA damage-induced S and G2/M cell cycle arrest requires mTORC2-dependent regulation of Chk1

mTOR signalling is commonly dysregulated in cancer. Concordantly, mTOR inhibitors have demonstrated efficacy in a subset of tumors and are in clinical trials as combination therapies. Although mTOR is associated with promoting cell survival after DNA damage, the exact mechanisms are not well underst...

Descripción completa

Detalles Bibliográficos
Autores principales: Selvarajah, Jogitha, Elia, Androulla, Carroll, Veronica A., Moumen, Abdeladim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381605/
https://www.ncbi.nlm.nih.gov/pubmed/25460505

Ejemplares similares

Ejemplares similares