Poloxamer-based binary hydrogels for delivering tramadol hydrochloride: sol-gel transition studies, dissolution-release kinetics, in vitro toxicity, and pharmacological evaluation

In this work, poloxamer (PL)-based binary hydrogels, composed of PL 407 and PL 188, were studied with regard to the physicochemical aspects of sol-gel transition and pharmaceutical formulation issues such as dissolution-release profiles. In particular, we evaluated the cytotoxicity, genotoxicity, an...

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Detalles Bibliográficos
Autores principales: dos Santos, Ana Claudia Mendonça, Akkari, Alessandra Cristina Santos, Ferreira, Iasmin Rosanne Silva, Maruyama, Cintia Rodrigues, Pascoli, Monica, Guilherme, Viviane Aparecida, de Paula, Eneida, Fraceto, Leonardo Fernandes, de Lima, Renata, Melo, Patrícia da Silva, de Araujo, Daniele Ribeiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381629/
https://www.ncbi.nlm.nih.gov/pubmed/25848258
http://dx.doi.org/10.2147/IJN.S72337

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381629/
https://www.ncbi.nlm.nih.gov/pubmed/25848258
http://dx.doi.org/10.2147/IJN.S72337

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