Roles of Lymphocyte Kv1.3-Channels in the Pathogenesis of Renal Diseases and Novel Therapeutic Implications of Targeting the Channels

Delayed rectifier K(+)-channels (Kv1.3) are predominantly expressed in T lymphocytes. Based on patch-clamp studies, the channels play crucial roles in facilitating the calcium influx necessary to trigger lymphocyte activation and proliferation. Using selective channel inhibitors in experimental anim...

Descripción completa

Detalles Bibliográficos
Autor principal: Kazama, Itsuro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381730/
https://www.ncbi.nlm.nih.gov/pubmed/25866450
http://dx.doi.org/10.1155/2015/436572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381730/
https://www.ncbi.nlm.nih.gov/pubmed/25866450
http://dx.doi.org/10.1155/2015/436572

Ejemplares similares