How IGF-1 activates its receptor

The type I insulin-like growth factor receptor (IGF1R) is involved in growth and survival of normal and neoplastic cells. A ligand-dependent conformational change is thought to regulate IGF1R activity, but the nature of this change is unclear. We point out an underappreciated dimer in the crystal st...

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Detalles Bibliográficos
Autores principales: Kavran, Jennifer M, McCabe, Jacqueline M, Byrne, Patrick O, Connacher, Mary Katherine, Wang, Zhihong, Ramek, Alexander, Sarabipour, Sarvenaz, Shan, Yibing, Shaw, David E, Hristova, Kalina, Cole, Philip A, Leahy, Daniel J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Biochemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381924/
https://www.ncbi.nlm.nih.gov/pubmed/25255214
http://dx.doi.org/10.7554/eLife.03772

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4381924/
https://www.ncbi.nlm.nih.gov/pubmed/25255214
http://dx.doi.org/10.7554/eLife.03772

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