Genome-Destabilizing Effects Associated with Top1 Loss or Accumulation of Top1 Cleavage Complexes in Yeast

Topoisomerase 1 (Top1), a Type IB topoisomerase, functions to relieve transcription- and replication-associated torsional stress in DNA. We investigated the effects of Top1 on genome stability in Saccharomyces cerevisiae using two different assays. First, a sectoring assay that detects loss of heter...

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Detalles Bibliográficos
Autores principales: Andersen, Sabrina L., Sloan, Roketa S., Petes, Thomas D., Jinks-Robertson, Sue
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382028/
https://www.ncbi.nlm.nih.gov/pubmed/25830313
http://dx.doi.org/10.1371/journal.pgen.1005098

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382028/
https://www.ncbi.nlm.nih.gov/pubmed/25830313
http://dx.doi.org/10.1371/journal.pgen.1005098

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