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Adding Vitamin E-TPGS to the Formulation of Genexol-PM: Specially Mixed Micelles Improve Drug-Loading Ability and Cytotoxicity against Multidrug-Resistant Tumors Significantly

Genexol-PM, produced by Samyang Company (Korea) is an excellent preparation of paclitaxel (PTX) for clinical cancer treatment. However, it cannot resolve the issue of multidrug resistance (MDR)—a significant problem in the administration of PTX to cancer patients. To increase the efficacy of Genexol...

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Autores principales: Fan, Zhuoyang, Chen, Cheng, Pang, Xiaoying, Yu, Zhou, Qi, Yang, Chen, Xinyi, Liang, Huihui, Fang, Xiaoling, Sha, Xianyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382049/
https://www.ncbi.nlm.nih.gov/pubmed/25831130
http://dx.doi.org/10.1371/journal.pone.0120129
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author Fan, Zhuoyang
Chen, Cheng
Pang, Xiaoying
Yu, Zhou
Qi, Yang
Chen, Xinyi
Liang, Huihui
Fang, Xiaoling
Sha, Xianyi
author_facet Fan, Zhuoyang
Chen, Cheng
Pang, Xiaoying
Yu, Zhou
Qi, Yang
Chen, Xinyi
Liang, Huihui
Fang, Xiaoling
Sha, Xianyi
author_sort Fan, Zhuoyang
collection PubMed
description Genexol-PM, produced by Samyang Company (Korea) is an excellent preparation of paclitaxel (PTX) for clinical cancer treatment. However, it cannot resolve the issue of multidrug resistance (MDR)—a significant problem in the administration of PTX to cancer patients. To increase the efficacy of Genexol-PM against MDR tumors, a mixed micelle capable of serving as a vehicle for PTX was developed, and two substances were chosen as carrier materials: 1) Polyethylene glycol–polylactic acid (PEG-PLA), the original vehicle of Genexol-PM. 2) Vitamin E-TPGS, an inhibitor of P-glycoprotein (P-gp). P-gp has been proven to be the main cause of MDR. In vitro evaluation indicated that the mixed micelle was an ideal PTX delivery system for the treatment of MDR tumors; the mixed micelle also showed a significantly better drug-loading coefficient than Genexol-PM.
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spelling pubmed-43820492015-04-09 Adding Vitamin E-TPGS to the Formulation of Genexol-PM: Specially Mixed Micelles Improve Drug-Loading Ability and Cytotoxicity against Multidrug-Resistant Tumors Significantly Fan, Zhuoyang Chen, Cheng Pang, Xiaoying Yu, Zhou Qi, Yang Chen, Xinyi Liang, Huihui Fang, Xiaoling Sha, Xianyi PLoS One Research Article Genexol-PM, produced by Samyang Company (Korea) is an excellent preparation of paclitaxel (PTX) for clinical cancer treatment. However, it cannot resolve the issue of multidrug resistance (MDR)—a significant problem in the administration of PTX to cancer patients. To increase the efficacy of Genexol-PM against MDR tumors, a mixed micelle capable of serving as a vehicle for PTX was developed, and two substances were chosen as carrier materials: 1) Polyethylene glycol–polylactic acid (PEG-PLA), the original vehicle of Genexol-PM. 2) Vitamin E-TPGS, an inhibitor of P-glycoprotein (P-gp). P-gp has been proven to be the main cause of MDR. In vitro evaluation indicated that the mixed micelle was an ideal PTX delivery system for the treatment of MDR tumors; the mixed micelle also showed a significantly better drug-loading coefficient than Genexol-PM. Public Library of Science 2015-04-01 /pmc/articles/PMC4382049/ /pubmed/25831130 http://dx.doi.org/10.1371/journal.pone.0120129 Text en © 2015 Fan et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Fan, Zhuoyang
Chen, Cheng
Pang, Xiaoying
Yu, Zhou
Qi, Yang
Chen, Xinyi
Liang, Huihui
Fang, Xiaoling
Sha, Xianyi
Adding Vitamin E-TPGS to the Formulation of Genexol-PM: Specially Mixed Micelles Improve Drug-Loading Ability and Cytotoxicity against Multidrug-Resistant Tumors Significantly
title Adding Vitamin E-TPGS to the Formulation of Genexol-PM: Specially Mixed Micelles Improve Drug-Loading Ability and Cytotoxicity against Multidrug-Resistant Tumors Significantly
title_full Adding Vitamin E-TPGS to the Formulation of Genexol-PM: Specially Mixed Micelles Improve Drug-Loading Ability and Cytotoxicity against Multidrug-Resistant Tumors Significantly
title_fullStr Adding Vitamin E-TPGS to the Formulation of Genexol-PM: Specially Mixed Micelles Improve Drug-Loading Ability and Cytotoxicity against Multidrug-Resistant Tumors Significantly
title_full_unstemmed Adding Vitamin E-TPGS to the Formulation of Genexol-PM: Specially Mixed Micelles Improve Drug-Loading Ability and Cytotoxicity against Multidrug-Resistant Tumors Significantly
title_short Adding Vitamin E-TPGS to the Formulation of Genexol-PM: Specially Mixed Micelles Improve Drug-Loading Ability and Cytotoxicity against Multidrug-Resistant Tumors Significantly
title_sort adding vitamin e-tpgs to the formulation of genexol-pm: specially mixed micelles improve drug-loading ability and cytotoxicity against multidrug-resistant tumors significantly
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382049/
https://www.ncbi.nlm.nih.gov/pubmed/25831130
http://dx.doi.org/10.1371/journal.pone.0120129
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