Analyses of the Transcriptome and Metabolome Demonstrate That HIF1α Mediates Altered Tumor Metabolism in Clear Cell Renal Cell Carcinoma

Hypoxia inducible factor 1 alpha (HIF1α) is a transcription factor that is frequently stabilized and active in human clear cell renal cell carcinoma (ccRCC). We have found that constitutively active HIF1α is sufficient to cause neoplastic transformation in a murine model of ccRCC termed the TRACK mo...

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Detalles Bibliográficos
Autores principales: Minton, Denise R., Fu, Leiping, Chen, Qiuying, Robinson, Brian D., Gross, Steven S., Nanus, David M., Gudas, Lorraine J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382166/
https://www.ncbi.nlm.nih.gov/pubmed/25830305
http://dx.doi.org/10.1371/journal.pone.0120649

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382166/
https://www.ncbi.nlm.nih.gov/pubmed/25830305
http://dx.doi.org/10.1371/journal.pone.0120649

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