Effects of ALDH2 Genotype, PPI Treatment and L-Cysteine on Carcinogenic Acetaldehyde in Gastric Juice and Saliva after Intragastric Alcohol Administration

Acetaldehyde (ACH) associated with alcoholic beverages is Group 1 carcinogen to humans (IARC/WHO). Aldehyde dehydrogenase (ALDH2), a major ACH eliminating enzyme, is genetically deficient in 30–50% of Eastern Asians. In alcohol drinkers, ALDH2-deficiency is a well-known risk factor for upper aerodig...

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Detalles Bibliográficos
Autores principales: Maejima, Ryuhei, Iijima, Katsunori, Kaihovaara, Pertti, Hatta, Waku, Koike, Tomoyuki, Imatani, Akira, Shimosegawa, Tooru, Salaspuro, Mikko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382225/
https://www.ncbi.nlm.nih.gov/pubmed/25831092
http://dx.doi.org/10.1371/journal.pone.0120397

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382225/
https://www.ncbi.nlm.nih.gov/pubmed/25831092
http://dx.doi.org/10.1371/journal.pone.0120397

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