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A Conserved Transcriptional Signature of Delayed Aging and Reduced Disease Vulnerability Is Partially Mediated by SIRT3

Aging is the most significant risk factor for a range of diseases, including many cancers, neurodegeneration, cardiovascular disease, and diabetes. Caloric restriction (CR) without malnutrition delays aging in diverse species, and therefore offers unique insights into age-related disease vulnerabili...

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Autores principales: Barger, Jamie L., Anderson, Rozalyn M., Newton, Michael A., da Silva, Cristina, Vann, James A., Pugh, Thomas D., Someya, Shinichi, Prolla, Tomas A., Weindruch, Richard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382298/
https://www.ncbi.nlm.nih.gov/pubmed/25830335
http://dx.doi.org/10.1371/journal.pone.0120738
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author Barger, Jamie L.
Anderson, Rozalyn M.
Newton, Michael A.
da Silva, Cristina
Vann, James A.
Pugh, Thomas D.
Someya, Shinichi
Prolla, Tomas A.
Weindruch, Richard
author_facet Barger, Jamie L.
Anderson, Rozalyn M.
Newton, Michael A.
da Silva, Cristina
Vann, James A.
Pugh, Thomas D.
Someya, Shinichi
Prolla, Tomas A.
Weindruch, Richard
author_sort Barger, Jamie L.
collection PubMed
description Aging is the most significant risk factor for a range of diseases, including many cancers, neurodegeneration, cardiovascular disease, and diabetes. Caloric restriction (CR) without malnutrition delays aging in diverse species, and therefore offers unique insights into age-related disease vulnerability. Previous studies suggest that there are shared mechanisms of disease resistance associated with delayed aging, however quantitative support is lacking. We therefore sought to identify a common response to CR in diverse tissues and species and determine whether this signature would reflect health status independent of aging. We analyzed gene expression datasets from eight tissues of mice subjected to CR and identified a common transcriptional signature that includes functional categories of mitochondrial energy metabolism, inflammation and ribosomal structure. This signature is detected in flies, rats, and rhesus monkeys on CR, indicating aspects of CR that are evolutionarily conserved. Detection of the signature in mouse genetic models of slowed aging indicates that it is not unique to CR but rather a common aspect of extended longevity. Mice lacking the NAD-dependent deacetylase SIRT3 fail to induce mitochondrial and anti-inflammatory elements of the signature in response to CR, suggesting a potential mechanism involving SIRT3. The inverse of this transcriptional signature is detected with consumption of a high fat diet, obesity and metabolic disease, and is reversed in response to interventions that decrease disease risk. We propose that this evolutionarily conserved, tissue-independent, transcriptional signature of delayed aging and reduced disease vulnerability is a promising target for developing therapies for age-related diseases.
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spelling pubmed-43822982015-04-09 A Conserved Transcriptional Signature of Delayed Aging and Reduced Disease Vulnerability Is Partially Mediated by SIRT3 Barger, Jamie L. Anderson, Rozalyn M. Newton, Michael A. da Silva, Cristina Vann, James A. Pugh, Thomas D. Someya, Shinichi Prolla, Tomas A. Weindruch, Richard PLoS One Research Article Aging is the most significant risk factor for a range of diseases, including many cancers, neurodegeneration, cardiovascular disease, and diabetes. Caloric restriction (CR) without malnutrition delays aging in diverse species, and therefore offers unique insights into age-related disease vulnerability. Previous studies suggest that there are shared mechanisms of disease resistance associated with delayed aging, however quantitative support is lacking. We therefore sought to identify a common response to CR in diverse tissues and species and determine whether this signature would reflect health status independent of aging. We analyzed gene expression datasets from eight tissues of mice subjected to CR and identified a common transcriptional signature that includes functional categories of mitochondrial energy metabolism, inflammation and ribosomal structure. This signature is detected in flies, rats, and rhesus monkeys on CR, indicating aspects of CR that are evolutionarily conserved. Detection of the signature in mouse genetic models of slowed aging indicates that it is not unique to CR but rather a common aspect of extended longevity. Mice lacking the NAD-dependent deacetylase SIRT3 fail to induce mitochondrial and anti-inflammatory elements of the signature in response to CR, suggesting a potential mechanism involving SIRT3. The inverse of this transcriptional signature is detected with consumption of a high fat diet, obesity and metabolic disease, and is reversed in response to interventions that decrease disease risk. We propose that this evolutionarily conserved, tissue-independent, transcriptional signature of delayed aging and reduced disease vulnerability is a promising target for developing therapies for age-related diseases. Public Library of Science 2015-04-01 /pmc/articles/PMC4382298/ /pubmed/25830335 http://dx.doi.org/10.1371/journal.pone.0120738 Text en © 2015 Barger et al http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are properly credited.
spellingShingle Research Article
Barger, Jamie L.
Anderson, Rozalyn M.
Newton, Michael A.
da Silva, Cristina
Vann, James A.
Pugh, Thomas D.
Someya, Shinichi
Prolla, Tomas A.
Weindruch, Richard
A Conserved Transcriptional Signature of Delayed Aging and Reduced Disease Vulnerability Is Partially Mediated by SIRT3
title A Conserved Transcriptional Signature of Delayed Aging and Reduced Disease Vulnerability Is Partially Mediated by SIRT3
title_full A Conserved Transcriptional Signature of Delayed Aging and Reduced Disease Vulnerability Is Partially Mediated by SIRT3
title_fullStr A Conserved Transcriptional Signature of Delayed Aging and Reduced Disease Vulnerability Is Partially Mediated by SIRT3
title_full_unstemmed A Conserved Transcriptional Signature of Delayed Aging and Reduced Disease Vulnerability Is Partially Mediated by SIRT3
title_short A Conserved Transcriptional Signature of Delayed Aging and Reduced Disease Vulnerability Is Partially Mediated by SIRT3
title_sort conserved transcriptional signature of delayed aging and reduced disease vulnerability is partially mediated by sirt3
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382298/
https://www.ncbi.nlm.nih.gov/pubmed/25830335
http://dx.doi.org/10.1371/journal.pone.0120738
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