TRPM8 on mucosal sensory nerves regulates colitogenic responses by innate immune cells via CGRP

TRPM8 is the molecular sensor for cold; however, the physiological role of TRPM8+ neurons at mucosal surfaces is unclear. Here we evaluated the distribution and peptidergic properties of TRPM8+ fibers in naïve and inflamed colons, as well as their role in mucosal inflammation. We found that Trpm8(−/...

Descripción completa

Detalles Bibliográficos
Autores principales: de Jong, Petrus R., Takahashi, Naoki, Peiris, Madusha, Bertin, Samuel, Lee, Jihyung, Gareau, Melanie G., Paniagua, Alan, Harris, Alexandra R., Herdman, David S., Corr, Maripat, Blackshaw, L. Ashley, Raz, Eyal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382463/
https://www.ncbi.nlm.nih.gov/pubmed/25269705
http://dx.doi.org/10.1038/mi.2014.82

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382463/
https://www.ncbi.nlm.nih.gov/pubmed/25269705
http://dx.doi.org/10.1038/mi.2014.82

Ejemplares similares