Discovery of a capuramycin analog that kills non-replicating Mycobacterium tuberculosis and its synergistic effects with translocase I inhibitors

Capuramycin (1) and its analogs are strong translocase I (MurX/MraY) inhibitors. In our SAR studies of capuramycin analogs against M. tuberculosis (Mtb), we observed for the first time that a capuramycin analog, UT-01320 (3) killed non-replicating (dormant) Mtb at low concentrations under low-oxygen...

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Detalles Bibliográficos
Autores principales: Siricilla, Shajila, Mitachi, Katsuhiko, Wan, Bajoie, Franzblau, Scott G., Kurosu, Michio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382465/
https://www.ncbi.nlm.nih.gov/pubmed/25269459
http://dx.doi.org/10.1038/ja.2014.133

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382465/
https://www.ncbi.nlm.nih.gov/pubmed/25269459
http://dx.doi.org/10.1038/ja.2014.133

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