BRCA1 Is a Histone-H2A-Specific Ubiquitin Ligase

The RING domain proteins BRCA1 and BARD1 comprise a heterodimeric ubiquitin (E3) ligase that is required for the accumulation of ubiquitin conjugates at sites of DNA damage and for silencing at DNA satellite repeat regions. Despite its links to chromatin, the substrate and underlying function of the...

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Detalles Bibliográficos
Autores principales: Kalb, Reinhard, Mallery, Donna L., Larkin, Conor, Huang, Jeffrey T.J., Hiom, Kevin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2014
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382519/
https://www.ncbi.nlm.nih.gov/pubmed/25131202
http://dx.doi.org/10.1016/j.celrep.2014.07.025

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382519/
https://www.ncbi.nlm.nih.gov/pubmed/25131202
http://dx.doi.org/10.1016/j.celrep.2014.07.025

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