Artificial human Met agonists based on macrocycle scaffolds

Hepatocyte growth factor (HGF) receptor, also known as Met, is a member of the receptor tyrosine kinase family. The Met–HGF interaction regulates various signalling pathways involving downstream kinases, such as Akt and Erk. Met activation is implicated in wound healing of tissues via multiple biolo...

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Detalles Bibliográficos
Autores principales: Ito, Kenichiro, Sakai, Katsuya, Suzuki, Yoshinori, Ozawa, Naoya, Hatta, Tomohisa, Natsume, Tohru, Matsumoto, Kunio, Suga, Hiroaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Pub. Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382702/
https://www.ncbi.nlm.nih.gov/pubmed/25758345
http://dx.doi.org/10.1038/ncomms7373

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382702/
https://www.ncbi.nlm.nih.gov/pubmed/25758345
http://dx.doi.org/10.1038/ncomms7373

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