Cargando…

Adipose tissue NAPE-PLD controls fat mass development by altering the browning process and gut microbiota

Obesity is a pandemic disease associated with many metabolic alterations and involves several organs and systems. The endocannabinoid system (ECS) appears to be a key regulator of energy homeostasis and metabolism. Here we show that specific deletion of the ECS synthesizing enzyme, NAPE-PLD, in adip...

Descripción completa

Detalles Bibliográficos
Autores principales:	Geurts, Lucie, Everard, Amandine, Van Hul, Matthias, Essaghir, Ahmed, Duparc, Thibaut, Matamoros, Sébastien, Plovier, Hubert, Castel, Julien, Denis, Raphael G. P., Bergiers, Marie, Druart, Céline, Alhouayek, Mireille, Delzenne, Nathalie M., Muccioli, Giulio G., Demoulin, Jean-Baptiste, Luquet, Serge, Cani, Patrice D.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Pub. Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4382707/ https://www.ncbi.nlm.nih.gov/pubmed/25757720 http://dx.doi.org/10.1038/ncomms7495

Ejemplares similares

Hepatic NAPE-PLD Is a Key Regulator of Liver Lipid Metabolism
por: Lefort, Charlotte, et al.
Publicado: (2020)

NAPE-PLD in the ventral tegmental area regulates reward events, feeding and energy homeostasis
por: Castel, Julien, et al.
Publicado: (2023)

Hepatocyte MyD88 affects bile acids, gut microbiota and metabolome contributing to regulate glucose and lipid metabolism
por: Duparc, Thibaut, et al.
Publicado: (2017)

Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status
por: Everard, Amandine, et al.
Publicado: (2014)

Intestinal epithelial N-acylphosphatidylethanolamine phospholipase D links dietary fat to metabolic adaptations in obesity and steatosis
por: Everard, Amandine, et al.
Publicado: (2019)

Small Molecule Activation of NAPE-PLD Enhances Efferocytosis by Macrophages
por: Zarrow, Jonah E., et al.
Publicado: (2023)

High-fat diet feeding differentially affects the development of inflammation in the central nervous system
por: Guillemot-Legris, Owein, et al.
Publicado: (2016)

NAPE-PLD deletion in stress-TRAPed neurons results in an anxiogenic phenotype
por: Tevosian, Margaryta, et al.
Publicado: (2023)

Saccharomyces boulardii Administration Changes Gut Microbiota and Reduces Hepatic Steatosis, Low-Grade Inflammation, and Fat Mass in Obese and Type 2 Diabetic db/db Mice
por: Everard, Amandine, et al.
Publicado: (2014)

Nitric oxide positively affects endometrial receptivity via FAAH and NAPE-PLD in vitro
por: Melford, Sarah E, et al.
Publicado: (2021)

Inulin increases the beneficial effects of rhubarb supplementation on high-fat high-sugar diet-induced metabolic disorders in mice: impact on energy expenditure, brown adipose tissue activity, and microbiota
por: Régnier, Marion, et al.
Publicado: (2023)

Expression and localization of CB1R, NAPE-PLD, and FAAH in the vervet monkey nucleus accumbens
por: Kucera, Ryan, et al.
Publicado: (2018)

Hepatic MyD88 regulates liver inflammation by altering synthesis of oxysterols
por: Lefort, Charlotte, et al.
Publicado: (2019)

Dysosmobacter welbionis effects on glucose, lipid, and energy metabolism are associated with specific bioactive lipids
por: Moens de Hase, Emilie, et al.
Publicado: (2023)

Supplementation with Akkermansia muciniphila in overweight and obese human volunteers: a proof-of-concept exploratory study
por: Depommier, Clara, et al.
Publicado: (2019)

Expression of MUC-2, MUC-6, NAPE-PLD, IL-6 and IL-13 in Healthy and Metaplastic Bronchial Epithelium
por: Lohova, Elizabeta, et al.
Publicado: (2022)

Selective measurement of NAPE-PLD activity via a PLA(1/2)-resistant fluorogenic N-acyl-phosphatidylethanolamine analog
por: Zarrow, Jonah E., et al.
Publicado: (2021)

Pasteurized Akkermansia muciniphila increases whole-body energy expenditure and fecal energy excretion in diet-induced obese mice
por: Depommier, Clara, et al.
Publicado: (2020)

Tetrahydro iso-Alpha Acids from Hops Improve Glucose Homeostasis and Reduce Body Weight Gain and Metabolic Endotoxemia in High-Fat Diet-Fed Mice
por: Everard, Amandine, et al.
Publicado: (2012)

Toxicological safety evaluation of pasteurized Akkermansia muciniphila
por: Druart, Céline, et al.
Publicado: (2020)

Gut microbes participate in food preference alterations during obesity
por: de Wouters d’Oplinter, Alice, et al.
Publicado: (2021)

Chronic Endocannabinoid System Stimulation Induces Muscle Macrophage and Lipid Accumulation in Type 2 Diabetic Mice Independently of Metabolic Endotoxaemia
por: Geurts, Lucie, et al.
Publicado: (2013)

Akkermansia muciniphila inversely correlates with the onset of inflammation, altered adipose tissue metabolism and metabolic disorders during obesity in mice
por: Schneeberger, Marc, et al.
Publicado: (2015)

Targeting the gut microbiota with inulin-type fructans: preclinical demonstration of a novel approach in the management of endothelial dysfunction
por: Catry, Emilie, et al.
Publicado: (2018)

Serum metabolite profiling yields insights into health promoting effect of A. muciniphila in human volunteers with a metabolic syndrome
por: Depommier, Clara, et al.
Publicado: (2021)

Food Reward Alterations during Obesity Are Associated with Inflammation in the Striatum in Mice: Beneficial Effects of Akkermansia muciniphila
por: Huwart, Sabrina J. P., et al.
Publicado: (2022)

Prebiotics Supplementation Impact on the Reinforcing and Motivational Aspect of Feeding
por: Delbès, Anne-Sophie, et al.
Publicado: (2018)

NIEHS director receives inaugural NAPE Award.
Publicado: (1997)

A nanoparticle platform for combined mucosal healing and immunomodulation in inflammatory bowel disease treatment
por: Marotti, Valentina, et al.
Publicado: (2023)

Altered Gut Microbiota and Endocannabinoid System Tone in Obese and Diabetic Leptin-Resistant Mice: Impact on Apelin Regulation in Adipose Tissue
por: Geurts, Lucie, et al.
Publicado: (2011)

Dysosmobacter welbionis is a newly isolated human commensal bacterium preventing diet-induced obesity and metabolic disorders in mice
por: Le Roy, Tiphaine, et al.
Publicado: (2022)

NAPE to Study Effect of Air Pollution on Organ Systems
Publicado: (1994)

Changes in gut microbiota control inflammation in obese mice through a mechanism involving GLP-2-driven improvement of gut permeability
por: Cani, P D, et al.
Publicado: (2009)

Talking microbes: When gut bacteria interact with diet and host organs
por: Cani, Patrice D., et al.
Publicado: (2016)

Dereplication and Quantification of Major Compounds of Convolvulus arvensis L. Extracts and Assessment of Their Effect on LPS-Activated J774 Macrophages
por: Abdul Khaliq, Hafiz, et al.
Publicado: (2022)

Localization of peroxisome proliferator-activated receptor alpha (PPARα) and N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) in cells expressing the Ca(2+)-binding proteins calbindin, calretinin, and parvalbumin in the adult rat hippocampus
por: Rivera, Patricia, et al.
Publicado: (2014)

A Minimal Connected Network of Transcription Factors Regulated in Human Tumors and Its Application to the Quest for Universal Cancer Biomarkers
por: Essaghir, Ahmed, et al.
Publicado: (2012)

Pediatric Autoimmune or Primary Sclerosing Cholangitis: Metronidazole Effectiveness on Biochemical Data, Bile Acid Profile, and Gut Microbiota: A Pilot Study
por: Karemera, Manon, et al.
Publicado: (2023)

Role of the Lower and Upper Intestine in the Production and Absorption of Gut Microbiota-Derived PUFA Metabolites
por: Druart, Céline, et al.
Publicado: (2014)

Oxysterol levels and metabolism in the course of neuroinflammation: insights from in vitro and in vivo models
por: Mutemberezi, Valentin, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_4pdcd2l94podm8vf35ohn3f06b