RNA virus attenuation by codon pair deoptimisation is an artefact of increases in CpG/UpA dinucleotide frequencies

Mutating RNA virus genomes to alter codon pair (CP) frequencies and reduce translation efficiency has been advocated as a method to generate safe, attenuated virus vaccines. However, selection for disfavoured CPs leads to unintended increases in CpG and UpA dinucleotide frequencies that also attenua...

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Detalles Bibliográficos
Autores principales: Tulloch, Fiona, Atkinson, Nicky J, Evans, David J, Ryan, Martin D, Simmonds, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2014
Materias:
Genomics and Evolutionary Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383024/
https://www.ncbi.nlm.nih.gov/pubmed/25490153
http://dx.doi.org/10.7554/eLife.04531

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383024/
https://www.ncbi.nlm.nih.gov/pubmed/25490153
http://dx.doi.org/10.7554/eLife.04531

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