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Molecular insights into RNA and DNA helicase evolution from the determinants of specificity for a DEAD-box RNA helicase
How different helicase families with a conserved catalytic ‘helicase core’ evolved to function on varied RNA and DNA substrates by diverse mechanisms remains unclear. In this study, we used Mss116, a yeast DEAD-box protein that utilizes ATP to locally unwind dsRNA, to investigate helicase specificit...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2014
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383044/ https://www.ncbi.nlm.nih.gov/pubmed/25497230 http://dx.doi.org/10.7554/eLife.04630 |