Absolute quantification of somatic DNA alterations in human cancer

We developed a computational method (ABSOLUTE) that infers tumor purity and malignant cell ploidy directly from analysis of somatic DNA alterations. ABSOLUTE can detect subclonal heterogeneity, somatic homozygosity, and calculate statistical sensitivity to detect specific aberrations. We used ABSOLU...

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Detalles Bibliográficos
Autores principales: Carter, Scott L., Cibulskis, Kristian, Helman, Elena, McKenna, Aaron, Shen, Hui, Zack, Travis, Laird, Peter W., Onofrio, Robert C., Winckler, Wendy, Weir, Barbara A., Beroukhim, Rameen, Pellman, David, Levine, Douglas A., Lander, Eric S., Meyerson, Matthew, Getz, Gad
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2012
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383288/
https://www.ncbi.nlm.nih.gov/pubmed/22544022
http://dx.doi.org/10.1038/nbt.2203

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383288/
https://www.ncbi.nlm.nih.gov/pubmed/22544022
http://dx.doi.org/10.1038/nbt.2203

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