A feedback loop between nonsense-mediated decay and the retrogene DUX4 in facioscapulohumeral muscular dystrophy

Facioscapulohumeral muscular dystrophy (FSHD) is a muscular dystrophy caused by inefficient epigenetic repression of the D4Z4 macrosatellite array and somatic expression of the DUX4 retrogene. DUX4 is a double homeobox transcription factor that is normally expressed in the testis and causes apoptosi...

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Detalles Bibliográficos
Autores principales: Feng, Qing, Snider, Lauren, Jagannathan, Sujatha, Tawil, Rabi, van der Maarel, Silvère M, Tapscott, Stephen J, Bradley, Robert K
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Genomics and Evolutionary Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383350/
https://www.ncbi.nlm.nih.gov/pubmed/25564732
http://dx.doi.org/10.7554/eLife.04996

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383350/
https://www.ncbi.nlm.nih.gov/pubmed/25564732
http://dx.doi.org/10.7554/eLife.04996

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