Increased Autoimmune Diabetes in pIgR-Deficient NOD Mice Is Due to a "Hitchhiking" Interval that Refines the Genetic Effect of Idd5.4

Selective breeding to introduce a gene mutation from one mouse strain onto the genetic background of another strain invariably produces “hitchhiking” (i.e. flanking) genomic intervals, which may independently affect a disease trait of interest. To investigate a role for the polymeric Ig receptor in...

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Detalles Bibliográficos
Autores principales: Simpfendorfer, Kim R., Strugnell, Richard A., Brodnicki, Thomas C., Wijburg, Odilia L. C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383422/
https://www.ncbi.nlm.nih.gov/pubmed/25835383
http://dx.doi.org/10.1371/journal.pone.0121979

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383422/
https://www.ncbi.nlm.nih.gov/pubmed/25835383
http://dx.doi.org/10.1371/journal.pone.0121979

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