Sample Preparation and Extraction in Small Sample Volumes Suitable for Pediatric Clinical Studies: Challenges, Advances, and Experiences of a Bioanalytical HPLC-MS/MS Method Validation Using Enalapril and Enalaprilat

In USA and Europe, medicines agencies force the development of child-appropriate medications and intend to increase the availability of information on the pediatric use. This asks for bioanalytical methods which are able to deal with small sample volumes as the trial-related blood lost is very restr...

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Detalles Bibliográficos
Autores principales: Burckhardt, Bjoern B., Laeer, Stephanie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383429/
https://www.ncbi.nlm.nih.gov/pubmed/25873972
http://dx.doi.org/10.1155/2015/796249

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383429/
https://www.ncbi.nlm.nih.gov/pubmed/25873972
http://dx.doi.org/10.1155/2015/796249

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