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Hybrid Spreading Mechanisms and T Cell Activation Shape the Dynamics of HIV-1 Infection

HIV-1 can disseminate between susceptible cells by two mechanisms: cell-free infection following fluid-phase diffusion of virions and by highly-efficient direct cell-to-cell transmission at immune cell contacts. The contribution of this hybrid spreading mechanism, which is also a characteristic of s...

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Detalles Bibliográficos
Autores principales: Zhang, Changwang, Zhou, Shi, Groppelli, Elisabetta, Pellegrino, Pierre, Williams, Ian, Borrow, Persephone, Chain, Benjamin M., Jolly, Clare
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383537/
https://www.ncbi.nlm.nih.gov/pubmed/25837979
http://dx.doi.org/10.1371/journal.pcbi.1004179