G-protein independent coupling of the MC4R to Kir 7.1 in hypothalamic neurons

The regulated release of anorexigenic α-MSH and orexigenic Agouti-related protein (AgRP) from discrete hypothalamic arcuate neurons onto common target sites in the CNS plays a fundamental role in the regulation of energy homeostasis. Both peptides bind with high affinity to the melanocortin-4 recept...

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Detalles Bibliográficos
Autores principales: Ghamari-Langroudi, Masoud, Digby, Gregory J., Sebag, Julien A., Millhauser, Glenn L., Palomino, Rafael, Matthews, Robert, Gillyard, Taneisha, Panaro, Brandon L., Tough, Iain R., Cox, Helen M., Denton, Jerod S., Cone, Roger D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383680/
https://www.ncbi.nlm.nih.gov/pubmed/25600267
http://dx.doi.org/10.1038/nature14051

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383680/
https://www.ncbi.nlm.nih.gov/pubmed/25600267
http://dx.doi.org/10.1038/nature14051

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