γ(1)34.5-Deleted HSV-1 Expressing Human Cytomegalovirus IRS1 Gene Kills Human Glioblastoma Cells as Efficiently as Wild-type HSV-1 in Normoxia or Hypoxia

Pathophysiological hypoxia, which fosters the glioma stem-like cell (GSC) phenotype, is present in high-grade gliomas and has been linked to tumor development, invasiveness, and resistance to chemotherapy and radiation. Oncolytic virotherapy with engineered herpes simplex virus-1 (HSV-1) is a promis...

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Detalles Bibliográficos
Autores principales: Friedman, Gregory K., Nan, Li, Haas, Marilyn C., Kelly, Virginia M., Moore, Blake P., Langford, Catherine P., Xu, Hui, Han, Xiaosi, Beierle, Elizabeth A., Markert, James M., Cassady, Kevin A., Gillespie, G. Yancey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383690/
https://www.ncbi.nlm.nih.gov/pubmed/25427614
http://dx.doi.org/10.1038/gt.2014.107

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383690/
https://www.ncbi.nlm.nih.gov/pubmed/25427614
http://dx.doi.org/10.1038/gt.2014.107

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