Structural insight into mechanisms for dynamic regulation of PKM2

Pyruvate kinase isoform M2 (PKM2) converts phosphoenolpyruvate (PEP) to pyruvate and plays an important role in cancer metabolism. Here, we show that post-translational modifications and a patient-derived mutation regulate pyruvate kinase activity of PKM2 through modulating the conformation of the P...

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Detalles Bibliográficos
Autores principales: Wang, Ping, Sun, Chang, Zhu, Tingting, Xu, Yanhui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Higher Education Press 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383751/
https://www.ncbi.nlm.nih.gov/pubmed/25645022
http://dx.doi.org/10.1007/s13238-015-0132-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383751/
https://www.ncbi.nlm.nih.gov/pubmed/25645022
http://dx.doi.org/10.1007/s13238-015-0132-x

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