Calorie restriction increases telomerase activity, enhances autophagy, and improves diastolic dysfunction in diabetic rat hearts

The aims of this study were to investigate the impact of caloric restriction (CR) on cardiac telomere biology in an animal model of diabetes and to examine the signal transduction involved in cell senescence as well as cardiac function. Male 8-week-old Otsuka Long-Evans Tokushima fatty (OLETF) diabe...

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Detalles Bibliográficos
Autores principales: Makino, Naoki, Oyama, Jun-ichi, Maeda, Toyoki, Koyanagi, Masamichi, Higuchi, Yoshihiro, Tsuchida, Keiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383823/
https://www.ncbi.nlm.nih.gov/pubmed/25662949
http://dx.doi.org/10.1007/s11010-015-2327-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383823/
https://www.ncbi.nlm.nih.gov/pubmed/25662949
http://dx.doi.org/10.1007/s11010-015-2327-0

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