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Calorie restriction increases telomerase activity, enhances autophagy, and improves diastolic dysfunction in diabetic rat hearts
The aims of this study were to investigate the impact of caloric restriction (CR) on cardiac telomere biology in an animal model of diabetes and to examine the signal transduction involved in cell senescence as well as cardiac function. Male 8-week-old Otsuka Long-Evans Tokushima fatty (OLETF) diabe...
Autores principales: | Makino, Naoki, Oyama, Jun-ichi, Maeda, Toyoki, Koyanagi, Masamichi, Higuchi, Yoshihiro, Tsuchida, Keiko |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4383823/ https://www.ncbi.nlm.nih.gov/pubmed/25662949 http://dx.doi.org/10.1007/s11010-015-2327-0 |
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