Identification of a New Selective Chemical Inhibitor of Mutant Isocitrate Dehydrogenase-1

BACKGROUND: Recent genome-wide sequencing studies have identified unexpected genetic alterations in cancer. In particular, missense mutations in isocitrate dehydrogenase-1 (IDH1) at arginine 132, mostly substituted into histidine (IDH1-R132H) were observed to frequently occur in glioma patients. MET...

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Detalles Bibliográficos
Autores principales: Kim, Hyo-Joon, Choi, Bu Young, Keum, Young-Sam
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Cancer Prevention 2015
Materias:
Short Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384718/
https://www.ncbi.nlm.nih.gov/pubmed/25853107
http://dx.doi.org/10.15430/JCP.2015.20.1.78

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384718/
https://www.ncbi.nlm.nih.gov/pubmed/25853107
http://dx.doi.org/10.15430/JCP.2015.20.1.78

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