Regulation of EGFR signal transduction by analogue-to-digital conversion in endosomes

An outstanding question is how receptor tyrosine kinases (RTKs) determine different cell-fate decisions despite sharing the same signalling cascades. Here, we uncovered an unexpected mechanism of RTK trafficking in this process. By quantitative high-resolution FRET microscopy, we found that phosphor...

Descripción completa

Detalles Bibliográficos
Autores principales: Villaseñor, Roberto, Nonaka, Hidenori, Del Conte-Zerial, Perla, Kalaidzidis, Yannis, Zerial, Marino
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2015
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384751/
https://www.ncbi.nlm.nih.gov/pubmed/25650738
http://dx.doi.org/10.7554/eLife.06156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384751/
https://www.ncbi.nlm.nih.gov/pubmed/25650738
http://dx.doi.org/10.7554/eLife.06156

Ejemplares similares