Differential regulation of mTORC1 by leucine and glutamine

The mechanistic target of rapamycin (mTOR) complex 1 (mTORC1) integrates environmental and intracellular signals to regulate cell growth. Amino acids stimulate mTORC1 activation at the lysosome in a manner thought to be dependent on the Rag small guanosine triphosphatases (GTPases), the Ragulator co...

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Detalles Bibliográficos
Autores principales: Jewell, Jenna L., Kim, Young Chul, Russell, Ryan C., Yu, Fa-Xing, Park, Hyun Woo, Plouffe, Steven W., Tagliabracci, Vincent S., Guan, Kun-Liang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384888/
https://www.ncbi.nlm.nih.gov/pubmed/25567907
http://dx.doi.org/10.1126/science.1259472

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4384888/
https://www.ncbi.nlm.nih.gov/pubmed/25567907
http://dx.doi.org/10.1126/science.1259472

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