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A specialized molecular motion opens the Hv1 voltage-gated proton channel

The Hv1 proton channel is unique among voltage-gated channels for containing the pore and gate within its voltage-sensing domain (VSD). Opening of the pore has been proposed to include assembly of the selectivity filter between the third arginine (R3) of S4 and an aspartate of S1 (D1). We asked whet...

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Detalles Bibliográficos
Autores principales: Mony, Laetitia, Berger, Thomas K., Isacoff, Ehud Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385474/
https://www.ncbi.nlm.nih.gov/pubmed/25730777
http://dx.doi.org/10.1038/nsmb.2978