Thiopurines Induce Oxidative Stress in T-Lymphocytes: A Proteomic Approach

Thiopurines are extensively used immunosuppressants for the treatment of inflammatory bowel disease (IBD). The polymorphism of thiopurine S-methyltransferase (TPMT) influences thiopurine metabolism and therapy outcome. We used a TPMT knockdown (kd) model of human Jurkat T-lymphocytes cells to study...

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Detalles Bibliográficos
Autores principales: Misdaq, Misbah, Ziegler, Sonia, von Ahsen, Nicolas, Oellerich, Michael, Asif, Abdul R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385670/
https://www.ncbi.nlm.nih.gov/pubmed/25873760
http://dx.doi.org/10.1155/2015/434825

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385670/
https://www.ncbi.nlm.nih.gov/pubmed/25873760
http://dx.doi.org/10.1155/2015/434825

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