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Thiopurines Induce Oxidative Stress in T-Lymphocytes: A Proteomic Approach

Thiopurines are extensively used immunosuppressants for the treatment of inflammatory bowel disease (IBD). The polymorphism of thiopurine S-methyltransferase (TPMT) influences thiopurine metabolism and therapy outcome. We used a TPMT knockdown (kd) model of human Jurkat T-lymphocytes cells to study...

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Detalles Bibliográficos
Autores principales:	Misdaq, Misbah, Ziegler, Sonia, von Ahsen, Nicolas, Oellerich, Michael, Asif, Abdul R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi Publishing Corporation 2015
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385670/ https://www.ncbi.nlm.nih.gov/pubmed/25873760 http://dx.doi.org/10.1155/2015/434825

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