Blockade of the JNK Signalling as a Rational Therapeutic Approach to Modulate the Early and Late Steps of the Inflammatory Cascade in Polymicrobial Sepsis

Cecal ligation and puncture (CLP) is an experimental polymicrobial sepsis induced systemic inflammation that leads to acute organ failure. Aim of our study was to evaluate the effects of SP600125, a specific c-Jun NH(2)-terminal kinase (JNK) inhibitor, to modulate the early and late steps of the inf...

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Detalles Bibliográficos
Autores principales: Pizzino, Gabriele, Bitto, Alessandra, Pallio, Giovanni, Irrera, Natasha, Galfo, Federica, Interdonato, Monica, Mecchio, Anna, De Luca, Filippo, Minutoli, Letteria, Squadrito, Francesco, Altavilla, Domenica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2015
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385695/
https://www.ncbi.nlm.nih.gov/pubmed/25873765
http://dx.doi.org/10.1155/2015/591572

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385695/
https://www.ncbi.nlm.nih.gov/pubmed/25873765
http://dx.doi.org/10.1155/2015/591572

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