Fgf9 inhibition of meiotic differentiation in spermatogonia is mediated by Erk-dependent activation of Nodal-Smad2/3 signaling and is antagonized by Kit Ligand

Both fibroblast growth factor 9 (Fgf9) and Kit Ligand (Kl) signal through tyrosine kinase receptors, yet they exert opposite effects on meiotic differentiation in postnatal spermatogonia, Fgf9 acting as a meiosis-inhibiting substance and Kl acting as a promoter of the differentiation process. To und...

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Detalles Bibliográficos
Autores principales: Tassinari, V, Campolo, F, Cesarini, V, Todaro, F, Dolci, S, Rossi, P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385934/
https://www.ncbi.nlm.nih.gov/pubmed/25766327
http://dx.doi.org/10.1038/cddis.2015.56

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4385934/
https://www.ncbi.nlm.nih.gov/pubmed/25766327
http://dx.doi.org/10.1038/cddis.2015.56

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