Elucidating the in vivo fate of nanocrystals using a physiologically based pharmacokinetic model: a case study with the anticancer agent SNX-2112

INTRODUCTION: SNX-2112 is a promising anticancer agent but has poor solubility in both water and oil. In the study reported here, we aimed to develop a nanocrystal formulation for SNX-2112 and to determine the pharmacokinetic behaviors of the prepared nanocrystals. METHODS: Nanocrystals of SNX-2112...

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Detalles Bibliográficos
Autores principales: Dong, Dong, Wang, Xiao, Wang, Huailing, Zhang, Xingwang, Wang, Yifei, Wu, Baojian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2015
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386773/
https://www.ncbi.nlm.nih.gov/pubmed/25848269
http://dx.doi.org/10.2147/IJN.S79734

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4386773/
https://www.ncbi.nlm.nih.gov/pubmed/25848269
http://dx.doi.org/10.2147/IJN.S79734

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